{"id":64678,"date":"2024-04-17T14:18:57","date_gmt":"2024-04-17T14:18:57","guid":{"rendered":"https:\/\/pr.asianetpakistan.com\/?p=121407"},"modified":"2024-04-17T14:18:57","modified_gmt":"2024-04-17T14:18:57","slug":"derm-biome-pharmaceuticals-topical-therapy-shows-positive-results-in-preclinical-skin-cancer-trial-drug-prevents-the-development-of-precancerous-skin-conditions-and","status":"publish","type":"post","link":"https:\/\/southafricahorizon.com\/derm-biome-pharmaceuticals-topical-therapy-shows-positive-results-in-preclinical-skin-cancer-trial-drug-prevents-the-development-of-precancerous-skin-conditions-and\/","title":{"rendered":"Derm-Biome Pharmaceuticals\u2019 topical therapy shows positive results\u00a0in\u00a0preclinical skin cancer trial: drug prevents\u00a0the development of\u00a0precancerous skin conditions\u00a0and\u00a0treats\u00a0existing skin\u00a0cancers\u00a0with no observable\u00a0side effects."},"content":{"rendered":"
Precancer treatment with chemotherapy cream<\/h5>\n
\n
\"\"<\/a><\/p>\n

Image credit: Mag\u2019s Murphys Journey<\/p>\n<\/div>\n<\/div>\n

VANCOUVER, British Columbia, April 17, 2024 (GLOBE NEWSWIRE) — The rates of precancerous skin conditions\u00a0and skin cancers\u00a0are soaring in many parts of the world.\u00a0Actinic keratosis\u00a0(AK)\u00a0is the most common\u00a0form of\u00a0precancer,\u00a0with\u00a0over\u00a040 million\u00a0Americans a year developing this\u00a0condition.\u00a0Treating AKs before the cells become cancerous and\u00a0spread to other parts of the body\u00a0is\u00a0crucial.\u00a0For those patients with multiple AKs,\u00a0common treatment options are chemotherapy creams and photodynamic therapy.\u00a0Although effective, these treatments\u00a0come with\u00a0significant side effects,\u00a0such\u00a0as\u00a0redness,\u00a0blistering, and peeling,\u00a0with\u00a0recovery times\u00a0that\u00a0can be\u00a0lengthy and\u00a0uncomfortable.\u00a0The global actinic keratosis treatment market size is projected to reach as high as $10 billion USD\u00a0by\u00a02031, fuelled by increasing cases of AK and rising healthcare spending.<\/p>\n

Derm-Biome\u00a0Pharmaceuticals is a Vancouver-based\u00a0biopharmaceutical company that\u00a0has developed a\u00a0topical\u00a0anticancer\u00a0treatment\u00a0for\u00a0patients\u00a0with\u00a0or\u00a0at high risk of\u00a0developing\u00a0multiple\u00a0AKs.\u00a0In a\u00a0recent\u00a0UV-induced skin cancer\u00a0trial,\u00a0mice were exposed to UVB radiation over a period of 25 weeks. The\u00a0prolonged exposure mimics chronic sun exposure over\u00a0time and\u00a0replicates the gradual progression from\u00a0precancerous skin conditions\u00a0to\u00a0cutaneous squamous cell carcinoma (cSCC).\u00a0Topical application of Derm-Biome\u2019s compound prior to UVB exposure significantly reduced the number and size of precancer lesions,\u00a0while treatment blocked\u00a0the progression of\u00a0squamous cell carcinoma tumors.<\/p>\n

Fr\u00e9d\u00e9ric\u00a0Couture, Researcher\u00a0and Head of Pharmaceutical\u00a0Sciences\u00a0at TransBIOtech:\u00a0\u201cMy\u00a0research\u00a0group\u00a0conducted\u00a0this study\u00a0using\u00a0Derm-Biome\u2019s compound. The\u00a0compound exhibited a significant protective effect without toxicity or side effects.\u00a0Moreover, existing tumor progression was blocked with drug treatment.\u00a0We actually noticed an\u00a0improvement to\u00a0the look of skin\u00a0treated with the\u00a0compound.\u201d<\/p>\n

Dr. Poul Sorensen, University of British Columbia Professor and Distinguished Scientist at BC Cancer Research Centre, and Derm-Biome CSO: \u201cThe results of these studies are very promising. We tested our compound using a very aggressive UV-induced skin cancer model. We observed highly significant decreases in the number of tumors in treated mice\u00a0and\u00a0strong preventative effects when mice were\u00a0pretreated with the compound.\u00a0These findings suggest that our compound has great potential to be a highly effective and well-tolerated agent for both the treatment\u00a0and<\/em>\u00a0prevention of squamous cell carcinoma.\u201d<\/p>\n

Derm-Biome CEO Gordon Eberwein:\u00a0\u201cCurrently available topical treatments cause debilitating side effects that make them unattractive to patients.\u00a0There is a real need for safer and more targeted topical therapies.\u201d<\/p>\n

Derm-Biome expects to start topical formulation development this summer, with IND-enabling studies slated to begin in Q4.<\/p>\n

About Derm-Biome Pharmaceuticals, Inc.
\n<\/strong>Derm-Biome Pharmaceuticals, Inc. is a preclinical biopharmaceutical company dedicated to improving skin health. We are developing novel topical therapies for inflammatory skin diseases and precancer\/non-melanoma skin cancers that are both highly effective and well tolerated by skin.<\/p>\n

Derm-Biome\u00a0is\u00a0about to kick off\u00a0a $3M USD\u00a0seed\u00a0funding\u00a0round. For investor inquiries please contact:<\/p>\n

Gordon Eberwein
\ngeberwein@derm-biome.com<\/a><\/u>
\nhttps:\/\/derm-biomepharmaceuticals.com<\/a><\/u><\/p>\n

A photo accompanying this announcement is available at\u00a0https:\/\/www.globenewswire.com\/NewsRoom\/AttachmentNg\/54b222f0-2c93-417d-8bba-33853a2dd94a<\/a><\/p>\n

GlobeNewswire Distribution ID 9091271<\/p>\n","protected":false},"excerpt":{"rendered":"

Precancer treatment with chemotherapy cream VANCOUVER, British Columbia, April 17, 2024 (GLOBE NEWSWIRE) \u2014 The rates of precancerous skin conditions\u00a0and skin cancers\u00a0are soaring in many parts of the world.\u00a0Actinic keratosis\u00a0(AK)\u00a0is the most common\u00a0form of\u00a0precancer,\u00a0with\u00a0over\u00a040 million\u00a0Americans a year developing this\u00a0condition.\u00a0Treating AKs before the cells become cancerous and\u00a0spread to other parts of the body\u00a0is\u00a0crucial.\u00a0For those patients with [\u2026]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34,30],"tags":[],"yoast_head":"\nDerm-Biome Pharmaceuticals\u2019 topical therapy shows positive results\u00a0in\u00a0preclinical skin cancer trial: drug prevents\u00a0the development of\u00a0precancerous skin conditions\u00a0and\u00a0treats\u00a0existing 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VANCOUVER, British Columbia, April 17, 2024 (GLOBE NEWSWIRE) \u2014 The rates of precancerous skin conditions\u00a0and skin cancers\u00a0are soaring in many parts of the world.\u00a0Actinic keratosis\u00a0(AK)\u00a0is the most common\u00a0form of\u00a0precancer,\u00a0with\u00a0over\u00a040 million\u00a0Americans a year developing this\u00a0condition.\u00a0Treating AKs before the cells become cancerous and\u00a0spread to other parts of the body\u00a0is\u00a0crucial.\u00a0For those patients with [\u2026]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/southafricahorizon.com\/derm-biome-pharmaceuticals-topical-therapy-shows-positive-results-in-preclinical-skin-cancer-trial-drug-prevents-the-development-of-precancerous-skin-conditions-and\/\" \/>\n<meta property=\"og:site_name\" content=\"South Africa Horizon\" \/>\n<meta property=\"article:published_time\" content=\"2024-04-17T14:18:57+00:00\" \/>\n<meta property=\"og:image\" 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